Search: "estimates"

After you give a substantive answer or draft that the user may act on — advice or recommendations, drafted artifacts such as goals, plans, pitches, proposals, or emails, estimates or projections, analysis or interpretation of data, factual claims they may rely on, or a multi-step argument — invoke this skill BEFORE finalizing your reply and then, if it applies, append 2-3 short follow-up questions, each tied to something specific in what you just produced, that help the user check key facts, probe the reasoning or assumptions, and notice missing context. Do this at most once per conversation. Skip it when the user asked a trivial how-to or simple lookup, wants a purely educational explanation, asked you only to format, convert, or assemble a file from content they provided, is writing code they will run, is doing creative writing or casual chat, or already asked you to double-check, cite, or review — the skill file explains these boundaries and the exact output format.

Performs RNA velocity analysis with scVelo from spliced and unspliced single-cell RNA counts. Fits deterministic or dynamical models, examines gene phase portraits, builds velocity graphs, estimates relative latent time, and ranks velocity-associated genes. Use for directional trajectory hypotheses and kinetic-model diagnostics alongside Scanpy; velocity alone does not establish cell fate or causal drivers.

Triages a repository's open GitHub issues and pull requests via the gh CLI. Optionally reviews and merges ready PRs — incrementally merging passing automated/bot PRs and maintainer-approved ones, and spawning review subagents for never-reviewed ones — then closes already-resolved issues with comments citing the resolving PR or commit, cross-links issues with their pending fix PRs, and assigns local-only priority and change-size estimates for everything outstanding. Use when triaging, grooming, or reviewing a repository's open issues and PRs.

Use when estimating time, effort, cost, or complexity for features, projects, refactors, and bug backlogs. Produces defensible estimates via triage, decomposition, risk handling, and confidence intervals, with clear assumptions and validation steps.